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Applied Cancer Research Units

Princess Margaret Hospital Consortium

Investigators – Amit Oza (Princess Margaret Hospital) + 14 others from Toronto, Kingston, Ottawa, Hamilton, London, and Mississauga
Summary – The Princess Margaret Hospital consortium consists of a group of investigators located at the Princess Margaret and at regional cancer centres who carry out clinical trials of investigational cancer medicines. The group has received competitive funding from the United States National Cancer Institute to support this activity. Funding provided through the Applied Cancer Research Unit Program will provide the group with the administrative support needed to ensure that their studies incorporate important biologic endpoints and more efficiently meet regulatory standards.

Division of Cancer Care & Epidemiology

Investigators – Michael Brundage (Queen’s University) + 10 others in Kingston
Summary – The Division of Cancer Care and Epidemiology is a group of investigators at Queen’s who conduct research aimed at evaluating access to care, quality of care, system efficiencies and governance, and in so doing, strive to improve cancer outcomes by increasing the attainment of what is already potentially achievable in cancer control. Members of the group are also seeking to quantify cancer risks associated with environmental exposures, and the interaction of these factors with genetic factors, with an ultimate goal of primary cancer prevention. Funding provided through the Applied Cancer Research Unit Program will provide the group with the administrative support needed to coordinate their wide range of activities and with the programming and statistical capacity to make their databases more useful to Ontario investigators.

On-PROST: Ontario Patient Reported Outcomes of Symptoms and Toxicity

Investigators – Geoffrey Liu and Doris Howell (University Health Network) + 12 others from Toronto, Kingston and London
Summary – This group has assembled a large research team focused on developing and implementing Patient Reported Outcome Measures (PROMS). The eventual goal is to set up systems to collect information from patients electronically as part of routine care. In addition, the group will create a repository of genetic information that may allow the identification of patients who are more likely to develop severe symptoms from, for example, radiotherapy. Funding provided through the Applied Cancer Research Unit Program will provide the group with the capacity to set up necessary infrastructure and to carry out critical pilot studies.

SCREEN-NET ONTARIO: The Ontario Cancer Screening Research Network

Investigators – Larry Paszat (University of Toronto - Department of Health Policy, Management, and Evaluation) + 27 others from Toronto, Guelph, Sudbury, London and several locations outside Ontario
Summary – The goal of this group is to develop infrastructure and initiate to pilot studies of cancer screening with the aim of increasing the number of research proposals in this area developed by Ontario investigators and funded by peer-review agencies. Their ultimate intention is to generate research results that will improve cancer screening and prevention in Ontario and beyond. The group will focus on assembling the population based data needed to conduct this research and on creating a collection a biologic specimens obtained from patient with cancer detected at screening. Applied Cancer Research Unit funding will support these activities as well as pilot projects.

Personalized medicine with targeted and genome-wide sequencing

Investigators – Benjamin Neel (Princess Margaret Hospital) + 30 others from Toronto, Ottawa, Hamilton, and London
Summary - The overarching goal of this proposal is to create a state-of-the-art joint Genomics Research Unit (GRU) at the University Health Network-Princess Margaret Hospital (UHN-PMH) and the Ontario Institute for Cancer Research that successfully meets the challenge of making “personalized medicine” a reality. The group will establish a core infrastructure to conduct genetic sequencing of patient tumours and then will develop two specific clinical research projects that will be supported by external peer-reviewed funding, pharmaceutical partnership, foundation support, as well as in-kind support from the Ontario Institute of Cancer Research. Funding provided through the Applied Cancer Research Unit Program will support the staff needed to coordinate the activities of groups working in the several areas (imaging, pathology, sequencing, clinical trials, etc.) involved in the project.

Cancer Imaging / Cancer Imaging Network of Ontario: System Prototyping in Image-Guided Robotic Percutaneous Interventions

Investigators – Gabor Fichtinger (Queen’s) and two others in Toronto and London
Summary – The investigators aim to develop a computer software infrastructure (SPARKit) that will facilitate real time images to guide diagnostic (for example, biopsies) and therapeutic (for example, radiotherapy) interventions. The software will be customizable and re-usable in different settings. Funding provided through the Applied Cancer Research Unit Program will provide the group with support for the engineers needed to develop software. In turn, that software will be used for future projects.

Last modified: Thu, Feb 10, 2011
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