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Stem Cell Transplant

Complex Malignant Hematology Services in Ontario - 2017 Report

Cover ImageWe are pleased to provide a review of Complex Malignant Hematology and Hematopoietic Cell Therapy services in Ontario as of June 2017.

This is a complex and evolving area of clinical care that requires intensive resources, specialized facilities and a high degree of specialization for the healthcare providers involved. The demand for these services, including Hematopoietic Cell Therapy, has increased over time and is expected to continue to grow.

Read more about our progress in the last year and our recommendations for the future.

Stem cell transplantation is an essential component of treatment for some people with lymphoma, leukemia, myeloma and other hematological (blood) disorders. It involves administration of high-dose chemotherapy, sometimes accompanied by total body radiation, to destroy the diseased cells. These treatments also destroy the person's bone marrow. Immature stem cells are infused into the person with the intent to regenerate the marrow, which will then produce healthy blood cells.

Two types of stem cell transplant
Autologous (Auto) Transplant: Stem cells are harvested from the patient and frozen before the start of high-dose chemotherapy, then reinfused (transplanted) back into the patient after the course of high dose chemotherapy. Allogeneic (Allo) Transplant: Stem cells are harvested from a related donor (usually a sibling) or an unrelated donor (found through a donor registry) and then reinfused (transplanted) back into the patient after treatment, usually chemotherapy and/or radiation.  

Bone marrow plays an important role in manufacturing blood cells and building the immune system.

Guidelines and Position Statements

Position Statements
Immunization Following Stem Cell Transplant in Adults.
Evidence-Based Guidelines
For evidence-based guidance documents, go to Stem Cell Transplant Reports.

What is the role of the Stem Cell Transplant Program?

We focus on access, funding and quality assurance for treatment of adult patients in Ontario, in collaboration with transplant centres. We receive strategic and clinical guidance from the Stem Cell Transplant Steering Committee. 

We also work with the Program in Evidence-Based Care to develop clinical best practice guidelines and recommendation reports to ensure patients receive the highest quality of care. 

Stem Cell Transplant Centres in Ontario

Now Available: Booklet outlining the care pathways for patients with acute myeloid leukemia (AML).

This booklet outlines the three different pathways that a patient’s care may follow during treatment.

The treatment pathways are complex and you should review them with your health care team.

Download the Treatment Pathways for AML.
  • University Health Network
  • The Ottawa Hospital
  • Hamilton Health Sciences Centre
  • London Health Sciences Centre
  • Kingston General Hospital
  • Health Sciences North/Horizon Santé Nord

What is the Provincial Stem Cell Transplant Case Conference?

The Stem Cell Transplant Case Conference (SCT CC) facilitates discussion and recommendations about the appropriateness of stem cell transplant for individual patients in Ontario. The group considers complex cases for which defining treatment recommendations is challenging.

Referring physicians: To bring a case forward for discussion, contact the SCT CC coordinator, Brenda Leury, at

Last modified: Fri, Jul 28, 2017
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